The 1st Ayuh Ventures fund update

Kunal Sethi
3 min readMay 17, 2022

Let’s not forget why this team started Ayuh VenturesLongevity to address AGEing, redefining quality of life

Valuations, economy, inflation, war, recession, pull back et all are true, and Venture is all about “playing long term games over short term” is also true

Come for the impact & stay for the returns cause Markets will decide the success of Longevity

There is a lot of noise where we’re at currently, and this team puts its head down and continues supporting Longevity founders, in a transparent manner to grow the community. There are some confidential fund details that unfortunately I cannot share here :)

Our team has been working on solutions to solve the world’s greatest issues for a while now. We first started Prithvi Ventures in 2020 with the understanding that there can be no future without a healthy planet underpinning it. The last three years have demonstrated that without a content and healthy body and mind, the fruits of Prithvi cannot be enjoyed. There are a number of problems that humans continue to face that prevent them from living a joyful life — psychological, neurological, physical, sensory, and sexual & reproductive health issues for which there are few effective treatment options.

In recent decades, up to 50% of the global population was facing psychological distress of some kind, with an estimated 28% of the global population facing depression and similar global numbers for anxiety, PTSD, and sleep problems. Then, beginning in 2020 as a result of the COVID-19 pandemic and lockdowns, the global population of those with anxiety and depression surged by an additional 25%. Meanwhile, current treatments for a large segment of the population dealing with mental health disorders have shown to be ineffective and carry the risk of a number of side effects.

Similarly, physical, motor, or sensory dysfunction or impairment that can arise from disabilities at birth, traumatic injury, or illness can equally hinder one’s ability to live a full life. These include neurodegenerative diseases like Alzheimer’s disease, Parkinson’s disease, ALS, MS, or cerebral palsy, autoimmune diseases like rheumatoid arthritis, inflammatory bowel diseases and psoriasis, or other disabilities like deafness or hard of hearing, forms of paralysis, or communication problems. Despite nearly 15% of the global population living with some form of the aforementioned disabilities and 10% of the world suffering from chronic pain, there are shockingly few effective and scalable treatment options and few effective treatment or symptom management options for individuals in need. The same goes for sexual and reproductive health, including dysmenorrhea, premenstrual dysphoric disorder, hypoactive sexual desire disorder, dyspareunia, anorgasmia, premature ejaculation and delayed or inhibited ejaculation. More specifically, one area that is particularly overlooked is women’s sexual health despite women making up about half of the global population. Approximately 30% of men globally deal with premature ejaculation while up to 25% of women deal with menstrual irregularities and up to 30% of women deal with extremely severe symptoms of dysmenorrhea.

It would be hard to imagine that there is anyone who is untouched by any of these longevity-tarnishing disorders in some way or another. Whether personally or through watching family or friends suffer, all of us at Ayuh Ventures have witnessed the hardships and lack of treatment options available to ourselves or those we love. We refuse to accept the status quo treatment options as the best options. We are on a mission to support founders developing the most promising technologies that help us live more joyful lives.

We are excited to share that the Ayuh Ventures fund is charging 0% fund management fees to our fund investors in order to maximize the impact of the capital that we invest in longevity founders. Additionally, LPs can now invest in the fund via USDC directly without having to convert to cash. We are excited to take this step to continue strengthening our relationship with the crypto community. In 2021, Ayuh Ventures co-invested with LPs via 4 Longevity SPVs, and since its launch a little over two months ago, the Ayuh Ventures Fund has invested in 5 Longevity startups, with 1 more on closing later this month.

We are always seeking to grow and connect the dots within the global longevity community and have found taking a community-oriented approach to be of great mutual benefit to all. We also believe this will improve the impact & our returns in the long run. In this spirit, we welcome conversations with mission aligned investors, founders, and academics who share our mission to improve our longevity.

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Kunal Sethi

Cancer Survivor, Climate nerd & Longevity obsessed: Prithvi Ventures & Ayuh Ventures